Effect of Unilateral Intracerebroventricuar Injection of Kainic Acid on the Dendritic Intersections of Ca3 Neurons of Hippocampus at the End of 04 Weeks

نویسندگان

  • Surendran Sudarshan
  • Satheesha Nayak
  • Sampath Kumar Madhyastha
چکیده

Temporal lobe epilepsy (TLE), a chronic brain disorder characterized by recurrent seizures with temporal lobe origin is the most frequent type of epilepsy in humans. Mesial temporal sclerosis is seen in TLE, in addition to the complex partial seizures that might spread to cause convulsive seizures (1). Kainate model of temporal lobe epilepsy (TLE) is a well known model known to mimic hippocampal sclerosis, as seen in a patient with temporal lobe epilepsy. In this study, kainic acid was injected into the right lateral ventricle of 04 months Wistar rats to create the model of TLE. At the end of 04 weeks post intracerebroventricular injection of kainic acid, the changes in the number of dendritic intersections were quantified, both in the apical and basal dendrites, for the understanding of the dendritic modifications in TLE. There was a significant decrease seen in the apical dendritic intersections on the ipsilateral side and the basal dendritic intersections showed a decrease both on the ipsilateral and the contralateral sides. The experimental procedures and the results have been discussed.

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تاریخ انتشار 2013